A Device to Grow Human Stem and Progenitor Cells Based on Biofeedback Control
Project Number
1570
Description
The invention described here consists of a bioreactor device to be used for propagating human blood stem and progenitor cells, or other stem or progenitor cell populations. The principle of the device lies in controlling endogenously produced negative regulators of cell growth by measuring their concentration and by using this measurement to control the rate of media supplementation or negative cell removal. The control system for the device is based on a novel mathematical model and software program that predicts endogenous factor concentrations and regulates bioprocesses parameters.
